Endocrine Abstracts

A relationship between obesity, plasma leptin concentration and primary hyperparathyroidism has been previously reported. To test the hypothesis that leptin directly stimulates parathyroid hormone (PTH) secretion, in vivo and in vitro experiments were conducted. In the in vivo studies leptin (200 μg/kg, ip) was administered to lean and obese (mutants that do not express active leptin receptor) Zucker rats. The in vitro experiments were ...

Context: The determination of human chorionic gonadotropin (hCG) in cerebrospinal fluid (CSF) is useful for the differential diagnosis of suprasellar lesions. However, the concentrations that prove diagnostic for neurohypophyseal germinoma have not been well defined. In addition, the immunoassays used for such determination are the same as those applied in serum, and few studies have been performed regarding the validation of such techniques in CSF.Objec...

Introduction and objectives: In the 4th Workshop on Primary Hyperparathyroidism, it is recommended to perform BMD by DXA of third radius as well as lumbar spine and hip DXA in the initial assessment and follow up of patients with primary hyperparathyroidism. This test is not available in many centers, which means that only T Score values of the lumbar spine and hip are used to certify the absence of osteoporosis in asymptomatic patients wich conservative management is...

Introduction and objectives: Having frequent hypoglycaemias can enable the appareance of severe and unnoticed hypoglycaemias, as well as favouring vascular damage in these patients. Our objective is to evaluate de incidende of severe hypoglycaemias (SH) in patients with Diabetes Mellitus type 1 and the reduction of perceived hypoglycaemias.Material and methods: A prospective study was conducted. Patients attending to their Endocrinology appointments betw...

Introduction: Family hypobetalipoproteinemia (HBF) is a rare genetic disorder, in 50% of cases are due to mutations APOB gene, which leads to decreased values of total cholesterol, low density lipoprotein (LDL-cholesterol) and apo-B. It is inherited as an autosomal dominant and heterozygous carriers are usually asymptomatic.Clinical case: Thirty-two-year-old male with abdominal pain and diarrhea associated with food, no relevant history and physical exam...

Introduction: ‘Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance’ category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to report those thyroid fine-needle aspiration (FNA) results that are not easily classified into the benign, suspicious or malignant categories. In most cases, a repeated FNA results in a more definitive interpretation. Estimated risk of malignancy for an...

Introduction: Primary hyperparathyroidism is caused by a single adenoma in 85% of cases. This is why bilateral neck exploration seems to be a very aggressive procedure in a large number of cases. Intraoperative parathyroid hormone (IOPTH) monitoring could be a useful tool in primary hyperparathyroidism surgery allowing a less invasive surgical approach. The aim of our study is to evaluate the possible impact of the measurement of IOPTH during surgery.Met...

Introduction: There are new therapies indicated in medullary thyroid cancer (MTC) based on different molecular targets, that appear to be effective in some cases with advanced disease, although many are still under investigation.Material and methods: We retrospectively evaluated five cases of medullar thyroid advanced carcinoma that later were referred to Oncology Department for Chemotherapy treatment.Results: Five patients (mean a...